A study published in Nature Mental Health suggests that physical activity may help reduce depression severity, particularly among people with a higher genetic vulnerability. Researchers analyzed genetic information, electronic health records and Fitbit activity data from 23,517 adults in the United States. Greater physical activity, measured through daily steps and moderate-to-vigorous exercise, was associated with less severe depressive symptoms, with stronger associations among individuals with higher genetic risk. However, researchers found no significant interaction between physical activity and genetic risk for the likelihood of receiving a depression diagnosis. Since the study was observational, it cannot establish cause and effect. Further research is needed to determine whether exercise-based interventions can improve outcomes for people at greater genetic risk.
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