A large health-record analysis found that glucosamine use was associated with a 25% higher likelihood of mild cognitive impairment progressing to dementia. Lab experiments suggest the supplement may intensify an abnormal sugar-tagging process in the Alzheimer’s brain, offering a possible biological explanation for the link. However, researchers stress that the findings show an association only, and clinical trials are needed to determine whether glucosamine actually causes harm, so the results should be treated as a signal worth investigating rather than proof that the widely used joint supplement accelerates cognitive decline.
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