Researchers have uncovered how a common form of brain cancer, called IDH glioma, becomes more aggressive over time. By analyzing individual tumor cells from patients, the team found that as the cancer progresses, it loses DNA methylation—chemical marks that normally help regulate genes. This change allows more tumor cells to revert to immature, stem cell-like states that are highly adaptable, invasive, and resistant to treatment. The findings provide new insights into why these tumors become harder to treat and may explain why some patients respond poorly to current IDH-targeted therapies. The discovery could guide future treatments and improve prediction of disease progression.
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