Researchers have discovered that people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) have impaired glymphatic functionāthe brain’s natural waste clearance system. Using MRI scans, the study found that reduced waste removal may allow harmful metabolic byproducts to accumulate, potentially triggering neuroinflammation linked to brain fog and other symptoms. The researchers also found that poorer sleep was associated with reduced glymphatic function, highlighting the vital role of sleep in maintaining brain health. While further research is needed, these findings provide a possible biological explanation for cognitive symptoms in ME/CFS and may help guide future diagnostic tools and targeted treatments.
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