Our bodies run on circadian rhythms that influence DNA repair, cell division, metabolism and immune activity, and researchers are exploring whether cancer treatment can be timed to these biological cycles. This approach, known as chronotherapy, aims to deliver treatments when cancer cells may be more vulnerable while healthy tissues are better able to tolerate them. Studies of chemotherapy have reported reduced treatment-related toxicity in some patients, although improvements in survival and treatment effectiveness have been inconsistent. The ideal treatment time may also depend on the cancer type, medication, sex and an individual’s biological clock. Researchers are now investigating biomarkers, wearable devices and AI to help personalize treatment timing, but chronotherapy remains an emerging area of cancer research.
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