Researchers have identified 81 previously unknown genes that drive basal-like (triple-negative) breast cancer, one of the most aggressive and difficult-to-treat forms of the disease. Using a powerful new CRISPR-based gene-editing tool, scientists mapped how abnormal chromosomes fuel tumor growth and uncovered potential drug targets that had been missed in traditional laboratory studies. One gene, PLGRKT, emerged as a promising target by helping cancer cells survive in low-oxygen environments. Published in Nature, the findings could pave the way for more precise, effective therapies and offer new hope for patients with this challenging form of breast cancer.
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