A large study using data from the UK Biobank suggests that higher blood glucose levels may accelerate brain aging. Researchers combined MRI brain scans, blood metabolomics, genetics, and artificial intelligence to identify factors linked to an “older-looking” brain. Among nine significant blood metabolites, glucose showed the strongest association with accelerated brain aging. Higher glucose levels were also linked to an increased risk of dementia, Alzheimer’s disease, Parkinson’s disease, stroke, depression, and poorer cognitive performance. While the findings do not prove cause and effect in humans, they highlight blood sugar control as a potentially modifiable factor that could help protect brain health and reduce the risk of age-related neurological disorders.
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