Creatine, a popular supplement known for improving muscle strength and athletic performance, may also have potential as a treatment for depression. A recent review analyzed five randomized clinical trials involving 238 participants to evaluate its effects on mental health. While two studies involving women with major depressive disorder found that creatine enhanced the benefits of standard antidepressant treatment, three other trials showed no significant improvement. Researchers believe creatine may support brain function by increasing cellular energy, but the current evidence remains mixed. Larger, well-designed clinical trials are needed before creatine can be recommended as a routine treatment for depression.
Read more at ScienceDaily