Scientists have identified an enzyme called UBE2N that may act as a natural defense against the worsening of fatty liver disease, a condition affecting an estimated 100 million Americans. The enzyme helps liver cells clear away damaged mitochondria and break down fat, two processes that appear key to preventing the disease from advancing into MASH, a more dangerous stage marked by inflammation, scarring and lasting cell damage. The discovery points to a potential new therapeutic target, offering hope that boosting UBE2N activity could help intervene before fatty liver disease progresses to this more severe and harder-to-treat form.
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