A large international study has found that people with benign adrenal tumors who have persistently high cortisol levels face a significantly greater risk of worsening high blood pressure and other cardiometabolic problems. Researchers followed more than 2,500 patients for nearly seven years and discovered that cortisol levels changed over time in about 22% of cases, challenging the belief that a single hormone test is enough. Patients with consistently elevated cortisol had a 34% higher risk of uncontrolled hypertension. The findings suggest that repeated cortisol testing and closer monitoring may help identify high-risk patients and improve long-term heart and metabolic health.
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