Researchers have developed an ultrasensitive gold nanoparticle-based biosensor that can detect early-stage liver fibrosis using just a small blood sample. The device identifies PICP, a protein released during the formation of liver scar tissue, by measuring tiny electrical changes when the biomarker binds to antibodies on the sensor. In patient testing, the technology achieved 95.24% sensitivity and 100% specificity, accurately distinguishing people with liver fibrosis from healthy individuals. Because it requires only a simple blood test and no painful liver biopsy, the biosensor could pave the way for portable, affordable diagnostic devices that enable earlier detection and treatment of chronic liver disease.
Read more at MedicalXpress