In a groundbreaking study, scientists have genetically engineered hookworms to produce and deliver therapeutic molecules from inside a living host. Using CRISPR gene-editing technology, researchers modified the parasite Ancylostoma ceylanicum to secrete an antibody capable of partially neutralizing tetrodotoxin, the deadly poison found in pufferfish.
Tests in hamsters showed that the engineered worms successfully released the antitoxin into the bloodstream, demonstrating a completely new approach to drug delivery. Researchers believe future versions could be designed to treat chronic conditions such as inflammatory bowel disease, food allergies, and type 2 diabetes. Because hookworm infections can be easily controlled and eliminated with standard treatments, this innovative technology could open the door to a new generation of living, self-sustaining medicines.
Read more at LiveScience