Scientists have identified a promising new way to overcome one of cancer treatment’s biggest challenges: drug resistance. Cancer cells often evade therapy by repairing the DNA damage caused by treatment, allowing them to survive and continue growing.
Researchers discovered that a compound called UNI418 can block this DNA repair process, leaving cancer cells more vulnerable to attack. When UNI418 was combined with a PARP inhibitor—a class of cancer drugs that targets DNA repair pathways—previously resistant cancer cells became sensitive to treatment once again.
The findings highlight a potential new therapeutic approach that could improve the effectiveness of existing cancer treatments and help patients whose tumors have stopped responding to current therapies.
Read more at ScienceDaily